Blood Collection Tubes Influence Serum Ficolin-1 and Ficolin-2 Levels
نویسندگان
چکیده
منابع مشابه
Human L-Ficolin (Ficolin-2) and Its Clinical Significance
Human L-ficolin (P35, ficolin-2) is synthesised in the liver and secreted into the bloodstream where it is one of the major pattern recognition molecules of plasma/serum. Like other ficolins, it consists of a collagen-like tail region linked to a fibrinogen-related globular head; a basic triplet subunit arises via a collagen-like triple helix, and this then forms higher multimers (typically a 1...
متن کاملFicolin-2 Levels and FCN2 Haplotypes Influence Hepatitis B Infection Outcome in Vietnamese Patients
Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver. Ficolin-2 serum levels and FCN2 single nucleotide polymorphisms were associated to several infectious diseases. We initially screened the complete FCN2 gene in 48 healthy individuals of Vietnamese ethnicity. We genotyped a Vietnamese ...
متن کاملAssociation of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis
BACKGROUND Visceral leishmaniasis (VL), one of the neglected tropical diseases, is endemic in the Indian subcontinent. Ficolins are circulating serum proteins of the lectin complement system and involved in innate immunity. METHODS We have estimated ficolin-2 serum levels and analyzed the functional variants of the encoding gene FCN2 in 218 cases of VL and in 225 controls from an endemic regi...
متن کاملPolymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2.
The ficolin 1, 2 and 3 (derived from the FCN1, 2 and 3 genes, respectively) are homologous soluble pattern recognition molecules of importance for innate immunity, comprising collagen-like and fibrinogen-like domains, binding to sugar groups on different types of microorganisms. Serum concentration of Ficolin-2 varies considerably in healthy individuals. Thus, we speculated whether this could b...
متن کاملThe Interaction Pattern of Murine Serum Ficolin-A with Microorganisms
The ficolins are soluble pattern recognition molecules in the lectin pathway of complement, but the spectrum and mode of interaction with pathogens are largely unknown. In this study, we investigated the binding properties of the murine serum ficolin-A towards a panel of different clinical relevant microorganisms (N = 45) and compared the binding profile with human serum ficolin-2 and ficolin-3...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2013
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00607-13